Transcriptional control of neurogenesis in time and space
Bassem Hassan I Institut du Cerveau et de la Moelle Épinière (ICM) - Hôpital Pitié-Salpêtrière, France | [email protected]
The development of the nervous system requires the generation of neurons of the proper type, at the correct time and space and in the right ratios. These three axes of neurogenesis are essential for building circuits that process information in manner that results in appropriate behaviors. That neurons of different types are produced at different times and in different numbers suggests some level of coordination between the three fundamental axes of neuronal production. How these axes are coordinated in time and space is poorly understood. I will describe our efforts to contribute to these questions, focusing mainly on the gene regulatory mechanisms that underlie the spatio-temporally coordinated production of the correct numbers of neurons.
Bassem Hassan I Institut du Cerveau et de la Moelle Épinière (ICM) - Hôpital Pitié-Salpêtrière, France | [email protected]
The development of the nervous system requires the generation of neurons of the proper type, at the correct time and space and in the right ratios. These three axes of neurogenesis are essential for building circuits that process information in manner that results in appropriate behaviors. That neurons of different types are produced at different times and in different numbers suggests some level of coordination between the three fundamental axes of neuronal production. How these axes are coordinated in time and space is poorly understood. I will describe our efforts to contribute to these questions, focusing mainly on the gene regulatory mechanisms that underlie the spatio-temporally coordinated production of the correct numbers of neurons.